Example of scores resulting from stakeholder prioritization. a Review questions 1–4 on Bt crops and Cry toxin. Means of scores for each criterion (importance, expert disagreement, and public awareness) on a scale of 1 (lowest) to 5 (highest). Criteria: importance: the review question is of high importance for the impact assessment of GMOs; expert disagreement: There is expert disagreement on the review question; Public awareness: The review question is the subject of high public awareness. b Review questions 1–4 on Bt crops and Cry toxin 1–4: aggregated mean scores (mean scores across all three criteria). RQ: review questions: RQ1: Does the knowledge about the biology of B. thuringiensis and its action towards organisms (target and non-target) raise any new questions in relation to the risk assessment of CRY toxins produced by GM plants? RQ2: Does the knowledge about the mode of action of CRY toxins at the molecular level pose any issues for the risk assessment of CRY toxins produced by GMPs? RQ3: How is the phylogenetic relationship, related to mode of action and specificity, between CRY toxins? RQ4: What is the current evidence base to conclude on whether the effects of combined, stacked or pyramided CRY toxins, as produced by stacked GMPs, will be additive, synergistic or antagonistic?