| High | Medium | Low | |||
---|---|---|---|---|---|---|
Study design | BACI | 13 | BA or CI | 82 | N/A | – |
Replication at level of intervention | n > 5 | 5 | n = 1–4 | 42 | Unreplicated | 48 |
Control matching | Well matched at site selection/study initiation | 80 | Moderately matched at site selection/study initiation | 9 | Poorly matched at site selection/study initiation | 6 |
Measured outcome | Quantitative | 79 | Semi-quantitative or quantitative approximation | 13 | Qualitative | 3 |
Confounding factors | Intervention and comparator sites are homogenous during study | 74 | Intervention and comparator sites moderately comparable with respect to confounding factors during study | 10 | Intervention and comparator sites hardly comparable with respect to confounding factors during study or lacking information to judge | 11 |